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Metformin is a primary pharmacologic treatment for patients with type 2 diabetes and can be useful in preventing or delaying diabetes in patients with prediabetes, defined as a glycated hemoglobin (A1c) from 5.7% to 6.4%.

The action for metformin is unique when compared to other antihyperglycemic agents. Metformin lowers the production of glucose in the liver, as well as lowers the absorption of glucose in the intestine. Metformin 500 also improves insulin sensitivity by expanding muscle glucose uptake and use. Metformin 500 induces weight loss most likely through a loss of adipose tissue rather than a change in energy expenditure, as is seen with exercise.

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